Early results indicate that genetic differentiation between groups in India is likely to be as much as three times higher than differentiation within populations in Europe. This is a clear indicator of the existence of population bottlenecks in India similar to those among religious sects in the West.
As population bottlenecks are themselves indicators of genetic disorders, it stands to reason that the endogamous populations of India are likely to be rife with inherited diseases. However, as there has been little systematic research into identifying the genes responsible for disorders common to Indian endogamous groups, not much is known about which groups are likely to have what mutation.
Genetic matchmaking - Wikipedia
The little that we do know indicates that this is research worth doing. For instance, we know that there is a high probability that Vysyas carry a recessive mutation in their genome that results in reduced levels of butylcholinesterase in their body. If anyone with low levels of this protein is given anaesthesia, there is a good chance that they could go into prolonged, potentially fatal, muscular paralysis.
No doubt numerous other such genetic insights will surface if we begin to look for them in other endogamous groups. A good proportion of these insights could well mean the difference between life and death. With the rapidly falling cost of sequencing the whole human genome, it should be relatively easy to undertake a widespread genetic analysis of all the endogamous groups in India to correlate genetic markers unique to those specific groups with symptoms that have a high rate of occurrence.
This will give us a significant opportunity to improve medical outcomes by simply studying rare recessive traits in specific communities. If we can make progress in this direction, we should be able to introduce genetic matchmaking into the arranged marriage workflow so that along with horoscopes, parents are encouraged to match whole genome reports to ascertain whether their as yet unborn grandchildren run the risk of inheriting deleterious double recessive mutations.
If they don't meet your criteria then delete them or, add them to your maybe list to revisit another day. Our personality compatibility rating is based on the 16 "personality types" possible with personality typology developed by Carl Jung's and Isabel Briggs Myers'.
DNA Romance hinges upon the success of direct-to-consumer genomic companies; subscribers have to get their genotype from such a company to complete the matching process. Nature Biotechnology 35, —, Nov 9th, DNA Romance is a dating app different from others: Know Techie, December 11th, European Journal of Human Genetics 26, —, April 30th, Teen Vogue, Nov 17th, DNA Romance translates genomics information hidden in your DNA into actionable advice to help your personal dating life.
Matchmaking service that uses the results of already-available DNA tests.
Part of the challenge on DNA testing is that there is no outcome of it. So people get their DNA tested and get some bad information - oh, you have this propensity to Alzheimer's or Diabetes. So turning DNA information into something that is actually actionable is interesting to me. DNA Romance is open to people who are 23andMe.
Opinion | Genetic matchmaking can improve medical outcomes
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